Review the Research

Get summaries of key research on vitamin D and COVID-19

Vitamin D status is not associated with clinical severity of COVID-19 in pregnant women.

Take Home Message

This study suggested that clinical severity and pulmonary involvement of COVID-19 may not be associated with vitamin D status in pregnant women. 

Results

  • Serum 25(OH)D concentrations were found to be 36.6 ± 26.8 and 31.3 ± 20.7 nmol/L in pregnant women infected with SARS-CoV-2 and healthy controls, respectively (p = 0.001).  
  • The clinical severity of pregnant women with COVID-19 did not differ concerning vitamin D deficiency, even after excluding patients on vitamin supplementation.  
  • Testing positive for SARS-CoV-2 was not related to vitamin D status in the overall cohort of pregnant women.  
  • Pulmonary involvement of COVID-19 was found to be similar between patients with vitamin D deficiency and adequate vitamin D levels. 

 

Who

147 COVID-19 positive pregnant women who are symptomatic. 

Things to Keep in Mind

  • This study had a very small number of subjects. 
  • There were no controls for confounders but the subjects were of similar age, gestational week, and BMI.  

Author’s Conclusions

In conclusion, clinical severity and pulmonary involvement of COVID-19 may not be associated with vitamin D status in pregnant women. Vitamin D deficiency/adequacy rates were comparable in pregnant women infected with SARS-CoV-2 and healthy pregnant women. Given the overall high vitamin D deficiency rate, physicians should focus on establishing adequate vitamin D levels in pregnancy. Further well-designed studies with larger sample sizes and optimal vitamin D status are required.” 

Study Design

  • A prospective case–control study included 147 pregnant women with COVID-19 and 300 healthy pregnant matched controls.  
  • Serum 25-hydroxyvitamin (25(OH)D) concentrations were measured on admission.  
  • Patients with mild-to-moderate disease (n = 114, 77.6%) and severe-to-critical disease (n = 33, 22.4%) were classified as symptomatic patients who did not require oxygen support and those who received oxygen support, respectively. 
  • SARS-CoV-2 positivity rates, clinical severity of COVID-19, and pulmonary involvement were compared according to vitamin D status. 

Reference

Tekin AB, Yassa M, Birol P, Unlu SN, Sahin T, Buran AM, Ayanoglu E, Tug N. Vitamin D status is not associated with clinical severity of COVID-19 in pregnant women. Eur J Nutr. 2022 Mar;61(2):1035-1041. doi: 10.1007/s00394-021-02709-7. Epub 2021 Oct 28. PMID: 34713327; PMCID: PMC8553286.

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Research Summaries

Association of vitamin D deficiency with COVID‐19 infection severity: Systematic review and meta‐analysis

Association of vitamin D deficiency with COVID‐19 infection severity: Systematic review and meta‐analysis Take Home Message Vitamin D deficiency leads to poorer outcomes in individuals diagnosed with COVID-19.

Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness.

Pre-infection 25-hydroxyvitamin D3 levels and  association with severity of COVID-19 illness. Take Home Message Vitamin D deficiency is a predictive risk factor associated with poorer COVID-19 clinical disease course and mortality.

COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials.

COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials. Take Home Message Vitamin D use was associated with significant decrease in rates of COVID-19-related events

2022-09-13T14:30:05-05:00