Review the Research

Get summaries of key research on vitamin D and COVID-19

Vitamin D Levels are Associated with Blood Glucose and BMI in COVID-19 Patients, Predicting Disease Severity

 

Take Home Message

High prevalence of low vitamin D levels is associated with increased disease severity due to an increased immune-inflammatory response.  

Results

  • Vitamin D levels were on average 16.3 ng/mL and 68.2% of patients were deficient. 
  • Vitamin D deficiency was found more in male patients than female (77% vs. 48%). 
  • There was a negative correlation between vitamin D levels and Neutrophil/Lymphocyte ratio, CRP levels, and cytokine levels.  
  • Lower vitamin D levels were found in patients affected by severe disease (65%) compared to non-deficient patients (39%). 
  • Vitamin D levels were lower in hyperglycemic patients. 
  • Vitamin D levels negatively correlated with BMI (r = -0.26). 

Who

88 Adult patients admitted to San Raffaele University Hospital for COVID-19 during the first Italian wave (Male: 67%, Female: 33%; Age: 56.8 y/o).

Things to Keep in Mind

  • A possible direct relationship between vitamin D, body fat, age, COVID-19 infection, and COVID-19 severity is likely.  
  • Vitamin D deficiency may be the variable in the endocrine pathway that influences patient outcomes. 

 

Author’s Conclusions

We showed, for the first-time, a strict association of VD levels with blood GLU and BMI in COVID-19 patients. VD deficiency might be a novel common pathophysiological mechanism involved in the detrimental effect of hyperglycemia and adiposity on disease severity.

Study Design

Retrospective sub-study of the COVID-BioB study – a large prospective observational investigation.

Reference

di Filippo L, Allora A, Doga M, Formenti AM, Locatelli M, Rovere Querini P, Frara S, Giustina A. Vitamin D Levels Are Associated With Blood Glucose and BMI in COVID-19 Patients, Predicting Disease Severity. J Clin Endocrinol Metab. 2022 Jan 1;107(1): e348-e360. doi: 10.1210/clinem/dgab599. PMID: 34383926; PMCID: PMC8385994. 

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Research Summaries

Association of vitamin D deficiency with COVID‐19 infection severity: Systematic review and meta‐analysis

Association of vitamin D deficiency with COVID‐19 infection severity: Systematic review and meta‐analysis Take Home Message Vitamin D deficiency leads to poorer outcomes in individuals diagnosed with COVID-19.

Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness.

Pre-infection 25-hydroxyvitamin D3 levels and  association with severity of COVID-19 illness. Take Home Message Vitamin D deficiency is a predictive risk factor associated with poorer COVID-19 clinical disease course and mortality.

COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials.

COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials. Take Home Message Vitamin D use was associated with significant decrease in rates of COVID-19-related events

2022-09-09T11:02:37-05:00