Review the Research

Get summaries of key research on vitamin D and COVID-19

Study Summaries

Ongoing Studies

Explore current trials being conducted around the world focused on vitamin D and COVID-19.

Title Status Conditions Interventions Location
Vitamin D Supplementation in Pregnant Women at Risk and COVID-19 Not yet recruiting • Pregnancy Complications
• Covid19
• Vitamin D supplementation in pregnant women • Maria Jose Aguilar Cordero, Granada, Spain
Clinical Outcomes of High Dose Vitamin D Versus Standard Dose in COVID-19 Egyptian Patients Recruiting • Covid19
• Corona Virus Infection
• Cytokine Storm
• Vitamin D Deficiency
• Teachers Hospital, Cairo, Egypt
Effect of Vitamin D on Hospitalized Adults With COVID-19 Infection Recruiting • Covid19 • Cholecalciferol
• Placebo
• CHU Liège, Liège, Belgium
Baseline Vitamin D Deficiency and COVID-19 Disease Severity Recruiting • Vitamin D Deficiency
• Covid19
• Vitamin D • Parkview Medical Center, Pueblo, Colorado, United States
Efficacy of Vitamin D Treatment in Mortality Reduction Due to COVID-19. Recruiting • SAR
• SARS Pneumonia
• Vitamin D
• Joaquín Durán Cantolla, Vitoria-Gasteiz, Alava, Spain
Vitamin D3 Supplementation to Prevent Respiratory Tract Infections Recruiting • Respiratory Tract Infections
• Covid19
• Flu Like Illness
• Vitamin D supplementation • Cooper University Hospital, Camden, New Jersey, United States
Trial of Vitamin D to Reduce Risk and Severity of COVID-19 and Other Acute Respiratory Infections Active, not recruiting • Covid19
• Acute Respiratory Tract Infection
• Vitamin D • Queen Mary University of London, London, County (optional), United Kingdom
Effect of Vitamin D on Morbidity and Mortality of the COVID-19 Recruiting • COVID-19 • Cholecalciferol • Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
Vitamin D and COVID-19 Trial Recruiting • COVID-19 • vitamin D
• Placebo
• Brigham and Women’s Hospital, Boston, Massachusetts, United States
High Dose Vitamin-D Substitution in Patients With COVID-19: a Randomized Controlled, Multi Center Study Recruiting • Covid19
• Vitamin D Deficiency
• Corona Virus Infection
• Coronavirus
• SARS-CoV Infection
• Single high dose vitamin D
• Placebo
• Treatment as usual vitamin D
• Cantonal Hospital Aarau, Aarau, AG, Switzerland
• Cantonal Hospital Baselland Liestal, Liestal, BL, Switzerland
• Cantonal Hospital St. Gallen, Saint Gallen, SG, Switzerland
Vitamin D Status and Immune-inflammatory Status in Different UK Populations With COVID-19 Infection Not yet recruiting • Covid19 • no intervention • GSTT NHS Trust, London, United Kingdom
Efficacy of Vitamin D Treatment in Pediatric Patients Hospitalized by COVID-19 Recruiting • Covid19
• Vitamin D
• Children, Only
• Cholecalciferol • Hospital Centro Medico Nacional Siglo XXI, Mexico City, Distrito Federal, Mexico
Tele-health Enabled Clinical Trial for COVID-19 Not yet recruiting • SARS-CoV Infection • Vitamin D3 or Placebo
• Doctella telehealth monitoring
• Northwestern University, Chicago, Illinois, United States
N-terminal Pro B-type Natriuretic Peptide and Vitamin D Levels as Prognostic Markers in COVID-19 Pneumonia Recruiting • COVID19 Pneumonia • Pro BNP , Vitamin D • Kasr Alainy Cairo University, Cairo, Giza, Egypt
Prevention of COVID-19 With Oral Vitamin D Supplemental Therapy in Essential Healthcare Teams Recruiting • COVID-19 • Placebo
• Vitamin D
• CHUM, Montreal, Quebec, Canada
• CHU Sainte-Justine (CHUSJ), Montreal, Quebec, Canada
Vitamin D Supplementation in the Prevention and Mitigation of COVID-19 Infection Recruiting • COVID-19
• Vitamin D Deficiency
• Respiratory Viral Infection
• Daily Vitamin D3
• Daily placebo
• Bolus vitamin D3
• Bolus placebo
• Medical University of South Carolina, Charleston, South Carolina, United States
The Effect of D3 on Selected Cytokines Involved in Cytokine Storm in the Covid-19 Uninfected Jordanian People Enrolling by invitation • Cytokine Storm • Vitamin D3 • Mahmoud S Abu-Samak, Amman, Jordan
Influence of Military Preventive Policy for reCruit Training on COVID-19 Seroconversion Recruiting • SARS-CoV Infection
• Vitamin D Deficiency
• Covid19
• Acute Respiratory Tract Infection
• Vitamin D • Headingley and City campuses, Leeds Beckett University, Leeds, Yorkshire, United Kingdom
• Infantry Training Centre Catterick, Catterick Garrison, United Kingdom
Short Term, High Dose Vitamin D Supplementation for COVID-19 Active, not recruiting • COVID • Vit D • Deptt of Endocrinology, Chandigarh, India
Cholecalciferol to Improve the Outcomes of COVID-19 Patients Recruiting • COVID • Vitamin D
• Placebo
• Hospital de Alta Complejidad en Red El Cruce, Florencio Varela, Buenos Aires, Argentina
Do Vitamin D Levels Really Correlated With Disease Severity in COVID-19 Patients? Enrolling by invitation • COVID • vitamin d • Bursa City Hospital, Bursa, Dogankoy, Turkey
Oral 25-hydroxyvitamin D3 and COVID-19 Recruiting • COVID 19 • Oral 25-Hydroxyvitamin D3 • Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of
Investigating the Role of Vitamin D in the Morbidity of COVID-19 Patients Not yet recruiting • COVID-19
• Vitamin D Deficiency
• Tameside Hospital NHS Foundation Trust, Ashton-under-Lyne, Greater Manchester, United Kingdom
Vitamin D and COVID-19 Management Not yet recruiting • COVID-19 • Ddrops® products, 50,000 IU, Oral
• Vitamin D3
VITACOV: Vitamin D Polymorphisms and Severity of COVID-19 Infection Not yet recruiting • COVID-19 • Exposure • Cardiovascular Center at Universidade de Lisboa, Lisbon, Lisboa, Portugal
• Centro Hospitalar Universitário Lisboa Norte, Lisbon, Lisboa, Portugal
• Centro Hospitalar de São João, Oporto, Portugal
C0vid-19 and Vitamin D Supplementation: a Multicenter Randomized Controlled Trial of High Dose Versus Standard Dose Vitamin D3 in High-risk COVID-19 Patients (CoVitTrial) Recruiting • Coronavirus • cholecalciferol 200,000 IU
• cholecalciferol 50,000 IU
• CHU Angers, Angers, France
• CHU Bordeaux, Bordeaux, France
• CH Le Mans, Le Mans, France
• CHU Lille, Lille, France
• CHU Limoges, Limoges, France
• CHU Nantes, Nantes, France
• CHU Nice, Nice, France
• CHU Saint Etienne, Saint Etienne, France
• CH Saumur, Saumur, France
• CHU Tours, Tours, France
Vitamin D on Prevention and Treatment of COVID-19 Not yet recruiting • Patients Infected With COVID-19 • Vitamin D • Universidad de Granada, Granada, Andalucia, Spain
• Medicine Faculty, Granada, Spain

The Importance of Vitamin D

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  1. Liu X, Baylin A, Levy PD. Vitamin D deficiency and insufficiency among US adults: prevalence, predictors and clinical implications. British Journal of Nutrition. 2018;119(8):928-936.
  2. Holick MF. The vitamin D deficiency pandemic: a forgotten hormone important for health. Public health reviews. 2010;32(1):267-283.
  3. Amrein K, Scherkl M, Hoffmann M, et al. Vitamin D deficiency 2.0: an update on the current status worldwide. European journal of clinical nutrition. 2020;74(11):1498-1513.
  4. MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76(4):1536-1538.)
  5. Kweder H, Eidi H. Vitamin D deficiency in elderly: Risk factors and drugs impact on vitamin D status. Avicenna J Med. 2018;8(4):139-146. doi:10.4103/ajm.AJM_20_18). 3.
  6. Emmanuel M. K. Awumey, Devashis A. Mitra, Bruce W. Hollis, Rajiv Kumar, Norman H. Bell, Vitamin D Metabolism Is Altered in Asian Indians in the Southern United States: A Clinical Research Center Study, The Journal of Clinical Endocrinology & Metabolism. 1998; 83(1): 169–173,
  7. Castro JP, Penckofer S. The role of vitamin D in the health of Hispanic adults with diabetes. Hisp Health Care Int. 2014;12(2):90-8. doi: 10.1891/1540-4153.12.2.90. PMID: 24871915.
  8. Sassi F, Tamone C, D’Amelio P. Vitamin D: nutrient, hormone, and immunomodulator. Nutrients. 2018;10(11):1656.
  9. Hewlings SJ, Medeiros DM. Nutrition: Real People, Real Choices. Pearson Prentice Hall; 2009.
  10. Elliott ME, Binkley NC, Carnes M, Zimmerman DR, Petersen K, Knapp K, Behlke JM, Ahmann N, Kieser MA. Fracture risks for women in long-term care: high prevalence of calcaneal osteoporosis and hypovitaminosis D. Pharmacotherapy. 2003; Jun;23(6):702-10.
  11. Nair R, Maseeh A. Vitamin D: The “sunshine” vitamin. J Pharmacol Pharmacother. 2012; Apr;3(2):118-26.
  12. Bilezikian JP, Bikle D, Hewison M, et al.Mechanisms in Endocrinology: Vitamin D and COVID-19. European Journal of Endocrinology. 2020;183(5):R133-r147.
  13. van Etten E, Mathieu C. Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. The Journal of steroid biochemistry and molecular biology. 2005;97(1-2):93-101.
  14. Ginde AA, Mansbach JM, Camargo CA, Jr. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Archives of internal medicine. 2009;169(4):384-390.
  15. A Kempker, J., & S Martin, G. Vitamin D and sepsis: from associations to causal connections. Inflammation & Allergy-Drug Targets (Formerly Current Drug Targets-Inflammation & Allergy) (Discontinued). 2013; 12(4): 246-252.
  16. Zdrenghea, M. T., Makrinioti, H., Bagacean, C., Bush, A., Johnston, S. L., and Stanciu, L. A. Vitamin D modulation of innate immune responses to respiratory viral infections, Rev Med Virol. 2017; 27:e1909. doi: 10.1002/rmv.1909.
  17. Vetter V, Denizer G, Friedland LR, Krishnan J, Shapiro M. Understanding modern-day vaccines: what you need to know. Annals of medicine. 2018;50(2):110-120.
  18. Cannell JJ, Vieth R, Umhau JC, et al. Epidemic influenza and vitamin D. Epidemiology and infection. 2006;134(6):1129-1140.
  19. Martineau A R, Jolliffe D A, Hooper R L, Greenberg L, Aloia J F, Bergman P et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data BMJ. 2017; (356):i6583 doi:10.1136/bmj.i6583.
  20. Zabetakis I, Lordan R, Norton C, Tsoupras A. COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation. Nutrients. 2020 May 19;12(5):1466. doi: 10.3390/nu12051466. PMID: 32438620; PMCID: PMC7284818.
  21. Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. The Journal of clinical endocrinology and metabolism. 2011;96(1):53-58.
  22. Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003;77(1):204-210.
  23. Rosen CJ, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, et al. IOM committee members respond to Endocrine Society vitamin D guidelines. J Clin Endocrinol Metab. 2012;97:1146-52.
  24. MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011;96:1911-30.
  25. Amrein K, Scherkl M, Hoffmann M, et al. Vitamin D deficiency 2.0: an update on the current status worldwide. European journal of clinical nutrition. 2020;74(11):1498-1513.