Review the Research
Get summaries of key research on vitamin D and COVID-19
Study Summaries
Vitamin D and SARS-CoV2 Infection, Severity and Mortality: A Systematic Review and Meta-Analysis
Vitamin D and SARS-CoV2 Infection, Severity and Mortality: A Systematic Review and Meta-analysis Take Home Message Vitamin D supplementation was associated with a significantly lower risk
Effects of Vitamin D Serum Level on Morbidity and Mortality in Patients with COVID-19: A Systematic Review and Meta-Analysis
Effects of Vitamin D Serum Level on Morbidity and Mortality in Patients with COVID-19: A Systematic Review and Meta-Analysis Take Home Message his analysis reported no
Vitamin D Deficiency and Comorbidities as Risk Factors of COVID-19 Infection: A Systematic Review and Meta-Analysis
Vitamin D Deficiency and Comorbidities as Risk Factors of COVID-19 Infection: A Systematic Review and Meta-Analysis Take Home Message Low serum vitamin -D levels were significantly
Prognostic and Therapeutic Role of Vitamin D in COVID-19: Systematic Review and Meta-Analysis
Prognostic and Therapeutic Role of Vitamin D in COVID-19: Systematic Review and Meta-Analysis Take Home Message This meta-analysis found vitamin D deficiency/insufficiency increased susceptibility to COVID-19
Effects of Vitamin D Supplementation on COVID-19 Related Outcomes: A Systematic Review and Meta-Analysis
Effects of Vitamin D Supplementation on COVID-19 Related Outcomes: A Systematic Review and Meta-Analysis Take Home Message Vitamin D supplementation had no significant impact on the
Association of vitamin D deficiency with COVID‐19 infection severity: Systematic review and meta‐analysis
Association of vitamin D deficiency with COVID‐19 infection severity: Systematic review and meta‐analysis Take Home Message Vitamin D deficiency leads to poorer outcomes in individuals diagnosed
COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials.
COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials. Take Home Message Vitamin D use was associated with significant decrease
Does vitamin D supplementation reduce COVID-19 severity? – a systematic review
This systematic review reports that vitamin D supplementation is effective in reducing COVID19 severity
-
Changes in 25‐hydroxyvitamin D levels post‐vitamin D supplementation in people of Black and Asian ethnicities and its implications during COVID‐19 pandemic: A systematic review Gallery
Changes in 25‐hydroxyvitamin D levels post‐vitamin D supplementation in people of Black and Asian ethnicities and its implications during COVID‐19 pandemic: A systematic review
Changes in 25‐hydroxyvitamin D levels post‐vitamin D supplementation in people of Black and Asian ethnicities and its implications during COVID‐19 pandemic: A systematic review
This study recommends that people with darker skin supplement their diet with vitamin D3 through oral modes aiming to reduce the risk of adverse outcomes of...
Low vitamin D levels and prognosis in a COVID-19 pediatric population: a systematic review
Low vitamin D levels and prognosis in a COVID-19 pediatric population: a systematic review Take Home Message In this systematic review of publications studying vitamin D
Association of vitamin D deficiency with COVID-19 infection severity: Systematic review and meta-analysis
Association of vitamin D deficiency with COVID-19 infection severity: Systematic review and meta-analysis Take Home Message In this meta-analysis it is suggested that Vitamin D deficiency
A systematic review and meta-analysis of effect of vitamin D levels on the incidence of COVID-19
A systematic review and meta-analysis of effect of vitamin D levels on the incidence of COVID-19 Take Home Message This meta-analysis reported that there is a
The Impact of Vitamin D Level on COVID-19 Infection: Systematic Review and Meta-Analysis
The Impact of Vitamin D Level on COVID-19 Infection: Systematic Review and Meta-Analysis Take Home Message This meta-analysis suggests that sufficient vitamin D level in serum
Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis
Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis. Take Home Message This meta-analysis reported a positive association between vitamin D deficiency and the severity of
Association of Vitamin D Status with SARS-CoV-2 Infection or COVID-19 Severity: A Systematic Review and Meta-analysis
Association of Vitamin D Status with SARS-CoV-2 Infection or COVID-19 Severity: A Systematic Review and Meta-analysis Take Home Message This meta-analysis suggested that there is a
Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis
Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis. Take Home Message Vitamin D deficiency and obesity increases risk
Vitamin D supplementation and clinical outcomes in COVID-19: a systematic review and meta-analysis
Vitamin D supplementation and clinical outcomes in COVID-19: a systematic review and meta-analysis Take Home Message Vitamin D supplementation might be associated with improved clinical outcomes
The role of vitamin D in the age of COVID-19: A systematic review and meta-analysis.
The role of vitamin D in the age of COVID-19: A systematic review and meta-analysis. Take Home Message Low vitamin D status may influence whether or
The link between COVID-19 and Vitamin D (VIVID): A systematic review and meta-analysis.
The link between COVID-19 and Vitamin D (VIVID): A systematic review and meta-analysis. Take Home Message This meta-analysis suggested that there is no statistical association between
Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies
Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies Take Home Message Vitamin D deficiency and
Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis.
Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis. Take Home Message This systematic review and meta-analysis of 5 studies found no significant difference
Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study).
In this 40 person randomized, placebo-controlled study in India a greater proportion of vitamin D-deficient individuals with mildly symptomatic COVID-19 infections tested COVID-19 negative...
Effect of Vitamin D Supplementation on COVID-19 Patients: A Systematic Review and Meta-Analysis
Effect of Vitamin D Supplementation on COVID-19 Patients: A Systematic Review and Meta-Analysis Take Home Message This meta-analysis found that vitamin D supplementation significantly reduced mortality
Effect of Vitamin D Status on Adult COVID-19 Pneumonia Induced by Delta Variant: A Longitudinal, Real-World Cohort Study
Effect of Vitamin D Status on Adult COVID-19 Pneumonia Induced by Delta Variant: A Longitudinal, Real-World Cohort Study Take Home Message In this small observational study
Is the Vitamin D Status of Patients with COVID-19 Associated with Reduced Mortality? A Systematic Review and Meta-Analysis
Is the Vitamin D Status of Patients with COVID-19 Associated with Reduced Mortality? A Systematic Review and Meta-Analysis Take Home Message his meta-analysis found that overall
SARS-CoV-2 Infection-Blocking Immunity Post Natural Infection: The Role of Vitamin D
SARS-CoV-2 Infection-Blocking Immunity Post Natural Infection: The Role of Vitamin D Take Home Message Higher vitamin D levels before COVID-19 infection were significantly associated with protection
Influence of Strict Lockdown on Vitamin D Deficiency in Pregnant Women: A Word of Caution
Influence of Strict Lockdown on Vitamin D Deficiency in Pregnant Women: A Word of Caution Take Home Message Pregnant women had an increased prevalence of vitamin
-
Impact of Vitamin D3 Supplementation on COVID-19 Vaccine Response and Immunoglobulin G Antibodies in Deficient Women: A Randomized Controlled Trial Gallery
Impact of Vitamin D3 Supplementation on COVID-19 Vaccine Response and Immunoglobulin G Antibodies in Deficient Women: A Randomized Controlled Trial
Impact of Vitamin D3 Supplementation on COVID-19 Vaccine Response and Immunoglobulin G Antibodies in Deficient Women: A Randomized Controlled Trial
Impact of Vitamin D3 Supplementation on COVID-19 Vaccine Response and Immunoglobulin G Antibodies in Deficient Women: A Randomized Controlled Trial Take Home Message This small intervention
Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women
Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women Take Home Message This small study found that low serum vitamin D levels were
Towards a Future of Personalized Vaccinology: Study on Individual Variables Influencing the Antibody Response to the COVID-19 Vaccine
Towards a Future of Personalized Vaccinology: Study on Individual Variables Influencing the Antibody Response to the COVID-19 Vaccine Take Home Message Higher vitamin D levels were
The Impact of Serum Levels of Vitamin D3 and Its Metabolites on the Prognosis and Disease Severity of COVID-19
The Impact of Serum Levels of Vitamin D3 and Its Metabolites on the Prognosis and Disease Severity of COVID-19 Take Home Message This study found that
Effect of Vitamin D Supplementation on COVID-19 Patients: A Systematic Review and Meta-Analysis
Effect of Vitamin D Supplementation on COVID-19 Patients: A Systematic Review and Meta-Analysis Take Home Message This meta-analysis found that vitamin D supplementation significantly reduced mortality
Is the Vitamin D Status of Patients with COVID-19 Associated with Reduced Mortality? A Systematic Review and Meta-Analysis
Is the Vitamin D Status of Patients with COVID-19 Associated with Reduced Mortality? A Systematic Review and Meta-Analysis Take Home Message his meta-analysis found that overall
-
Hospital and Laboratory Outcomes of Patients with COVID-19 who Received Vitamin D Supplementation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Gallery
Hospital and Laboratory Outcomes of Patients with COVID-19 who Received Vitamin D Supplementation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Hospital and Laboratory Outcomes of Patients with COVID-19 who Received Vitamin D Supplementation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Hospital and Laboratory Outcomes of Patients with COVID-19 who Received Vitamin D Supplementation: A Systematic Review and Meta-Analysis...
-
Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis Gallery
Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis
Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis
Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial....
Vitamin D and SARS-CoV2 Infection, Severity and Mortality: A Systematic Review and Meta-Analysis
Vitamin D and SARS-CoV2 Infection, Severity and Mortality: A Systematic Review and Meta-analysis Take Home Message Vitamin D supplementation was associated with a significantly lower risk
Effects of Vitamin D Serum Level on Morbidity and Mortality in Patients with COVID-19: A Systematic Review and Meta-Analysis
Effects of Vitamin D Serum Level on Morbidity and Mortality in Patients with COVID-19: A Systematic Review and Meta-Analysis Take Home Message his analysis reported no
Vitamin D Deficiency and Comorbidities as Risk Factors of COVID-19 Infection: A Systematic Review and Meta-Analysis
Vitamin D Deficiency and Comorbidities as Risk Factors of COVID-19 Infection: A Systematic Review and Meta-Analysis Take Home Message Low serum vitamin -D levels were significantly
Prognostic and Therapeutic Role of Vitamin D in COVID-19: Systematic Review and Meta-Analysis
Prognostic and Therapeutic Role of Vitamin D in COVID-19: Systematic Review and Meta-Analysis Take Home Message This meta-analysis found vitamin D deficiency/insufficiency increased susceptibility to COVID-19
Effects of Vitamin D Supplementation on COVID-19 Related Outcomes: A Systematic Review and Meta-Analysis
Effects of Vitamin D Supplementation on COVID-19 Related Outcomes: A Systematic Review and Meta-Analysis Take Home Message Vitamin D supplementation had no significant impact on the
Effect of Vitamin D Supplementation on COVID-19 Patients: A Systematic Review and Meta-Analysis
Effect of Vitamin D Supplementation on COVID-19 Patients: A Systematic Review and Meta-Analysis Take Home Message This meta-analysis found that vitamin D supplementation significantly reduced mortality
-
Impact of Vitamin D3 Supplementation on COVID-19 Vaccine Response and Immunoglobulin G Antibodies in Deficient Women: A Randomized Controlled Trial Gallery
Impact of Vitamin D3 Supplementation on COVID-19 Vaccine Response and Immunoglobulin G Antibodies in Deficient Women: A Randomized Controlled Trial
Impact of Vitamin D3 Supplementation on COVID-19 Vaccine Response and Immunoglobulin G Antibodies in Deficient Women: A Randomized Controlled Trial
Impact of Vitamin D3 Supplementation on COVID-19 Vaccine Response and Immunoglobulin G Antibodies in Deficient Women: A Randomized Controlled Trial Take Home Message This small intervention
-
Hospital and Laboratory Outcomes of Patients with COVID-19 who Received Vitamin D Supplementation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Gallery
Hospital and Laboratory Outcomes of Patients with COVID-19 who Received Vitamin D Supplementation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Hospital and Laboratory Outcomes of Patients with COVID-19 who Received Vitamin D Supplementation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Hospital and Laboratory Outcomes of Patients with COVID-19 who Received Vitamin D Supplementation: A Systematic Review and Meta-Analysis...
-
Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis Gallery
Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis
Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis
Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial....
Vitamin D supplementation and COVID‑19 risk: a population‑based, cohort study
Supplementation with cholecalciferol or calcifediol helped subject to achieve serum 25OHD levels ≥30 ng/ml which were associated with better COVID-19 outcomes.
-
Changes in 25‐hydroxyvitamin D levels post‐vitamin D supplementation in people of Black and Asian ethnicities and its implications during COVID‐19 pandemic: A systematic review Gallery
Changes in 25‐hydroxyvitamin D levels post‐vitamin D supplementation in people of Black and Asian ethnicities and its implications during COVID‐19 pandemic: A systematic review
Changes in 25‐hydroxyvitamin D levels post‐vitamin D supplementation in people of Black and Asian ethnicities and its implications during COVID‐19 pandemic: A systematic review
This study recommends that people with darker skin supplement their diet with vitamin D3 through oral modes aiming to reduce the risk of adverse outcomes of...
Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease
Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease. Take Home Message In a prospective open-label
Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis.
Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis. Take Home Message This systematic review and meta-analysis of 5 studies found no significant difference
COVID-19 severity in relation to sociodemographics and vitamin D use
COVID-19 severity in relation to sociodemographics and vitamin D use. Take Home Message The aims of this observational study of 428 recovered COVID-19 patients in Iraq,
Effect of Vitamin D Status on Adult COVID-19 Pneumonia Induced by Delta Variant: A Longitudinal, Real-World Cohort Study
Effect of Vitamin D Status on Adult COVID-19 Pneumonia Induced by Delta Variant: A Longitudinal, Real-World Cohort Study Take Home Message In this small observational study
SARS-CoV-2 Infection-Blocking Immunity Post Natural Infection: The Role of Vitamin D
SARS-CoV-2 Infection-Blocking Immunity Post Natural Infection: The Role of Vitamin D Take Home Message Higher vitamin D levels before COVID-19 infection were significantly associated with protection
Influence of Strict Lockdown on Vitamin D Deficiency in Pregnant Women: A Word of Caution
Influence of Strict Lockdown on Vitamin D Deficiency in Pregnant Women: A Word of Caution Take Home Message Pregnant women had an increased prevalence of vitamin
Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women
Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women Take Home Message This small study found that low serum vitamin D levels were
Towards a Future of Personalized Vaccinology: Study on Individual Variables Influencing the Antibody Response to the COVID-19 Vaccine
Towards a Future of Personalized Vaccinology: Study on Individual Variables Influencing the Antibody Response to the COVID-19 Vaccine Take Home Message Higher vitamin D levels were
The Impact of Serum Levels of Vitamin D3 and Its Metabolites on the Prognosis and Disease Severity of COVID-19
The Impact of Serum Levels of Vitamin D3 and Its Metabolites on the Prognosis and Disease Severity of COVID-19 Take Home Message This study found that
Correlation between 25-hydroxyvitamin D/D3 Deficiency and COVID-19 Disease Severity in Adults from Northern Colorado
Correlation between 25-hydroxyvitamin D/D3 Deficiency and COVID-19 Disease Severity in Adults from Northern Colorado Take Home Message In this observational study, lower levels of vitamin D
Low Vitamin D Levels are Associated with Long COVID Syndrome in COVID-19 Survivors
Low Vitamin D Levels are Associated with Long COVID Syndrome in COVID-19 Survivors Take Home Message This study, conducted in Italy, found that patients with long
Association Between Vitamin D Supplementation and COVID-19 Infection and Mortality
Association Between Vitamin D Supplementation and COVID-19 Infection and Mortality Take Home Message Among VA (Veterans Administration) patients, vitamin D3 and vitamin D2 supplementation reduced the
Correlation between 25-hydroxyvitamin D/D3 Deficiency and COVID-19 Disease Severity in Adults from Northern Colorado
Correlation between 25-hydroxyvitamin D/D3 Deficiency and COVID-19 Disease Severity in Adults from Northern Colorado Take Home Message In this observational study, lower levels of vitamin D
Low Vitamin D Levels are Associated with Long COVID Syndrome in COVID-19 Survivors
Low Vitamin D Levels are Associated with Long COVID Syndrome in COVID-19 Survivors Take Home Message This study, conducted in Italy, found that patients with long
Association of Vitamin D and Severity of COVID-19 in Children
Association of Vitamin D and Severity of COVID-19 in Children Take Home Message There is an association between vitamin D and severity of COVID-19 symptoms in
Vitamin D and morbidity in children with multisystem inflammatory syndrome related to Covid-19.
Vitamin D and morbidity in children with multisystem inflammatory syndrome related to Covid-19. Take Home Message This study showed a potential association between severe vitamin D
Low vitamin D levels and prognosis in a COVID-19 pediatric population: a systematic review
Low vitamin D levels and prognosis in a COVID-19 pediatric population: a systematic review Take Home Message In this systematic review of publications studying vitamin D
-
The association between vitamin D levels and the clinical severity and inflammation markers in pediatric COVID-19 patients: single-center experience from a pandemic hospital Gallery
The association between vitamin D levels and the clinical severity and inflammation markers in pediatric COVID-19 patients: single-center experience from a pandemic hospital
The association between vitamin D levels and the clinical severity and inflammation markers in pediatric COVID-19 patients: single-center experience from a pandemic hospital
In this retrospective cohort study of 103 COVID-19 positive pediatric patients aged 1-17 years in Istanbul, Turkey, a deficient serum vitamin D level [<12 ng/mL (<30 nmol/l)] was associated with clinical severity and elevated markers of inflammation.
Is vitamin D deficiency a risk factor for COVID‐19 in children?
There is a potential connection between vitamin D level and COVID-19, but more studies in children are needed before any conclusions can be drawn.
Influence of Strict Lockdown on Vitamin D Deficiency in Pregnant Women: A Word of Caution
Influence of Strict Lockdown on Vitamin D Deficiency in Pregnant Women: A Word of Caution Take Home Message Pregnant women had an increased prevalence of vitamin
Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women
Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women Take Home Message This small study found that low serum vitamin D levels were
Pregnancy and COVID-19: The Possible Contribution of Vitamin D
Pregnancy and COVID-19: The Possible Contribution of Vitamin D Take Home Message This study demonstrates a role of vitamin D in affecting the clinical characteristics of
Vitamin D status is not associated with clinical severity of COVID-19 in pregnant women.
Vitamin D status is not associated with clinical severity of COVID-19 in pregnant women. Take Home Message This study suggested that clinical severity and pulmonary involvement of
Impact of vitamin D on the course of COVID-19 during pregnancy: A case control study
Impact of vitamin D on the course of COVID-19 during pregnancy: A case control study Take Home Message Vitamin D deficiency may be a risk factor
Vitamin D status and outcomes for hospitalised older patients with COVID-19.
Vitamin D status and outcomes for hospitalised older patients with COVID-19. Take Home Message Older patients with COVID-19 infection and vitamin D deficiency (≤30 nmol/L) have
-
Serum Levels of Vitamin C and Vitamin D in a Cohort of Critically Ill COVID-19 Patients of a North American Community Hospital Intensive Care Unit in May 2020: A Pilot Study. Gallery
Serum Levels of Vitamin C and Vitamin D in a Cohort of Critically Ill COVID-19 Patients of a North American Community Hospital Intensive Care Unit in May 2020: A Pilot Study.
Serum Levels of Vitamin C and Vitamin D in a Cohort of Critically Ill COVID-19 Patients of a North American Community Hospital Intensive Care Unit in May 2020: A Pilot Study.
Results of this pilot study support the need for further research to determine if vitamin C and vitamin D status should be assessed upon admission for COVID-19...
COVID-19 mortality increases with northerly latitude after adjustment for age suggesting a link with ultraviolet and vitamin D.
This study investigated the relationships between latitude, age of population, population density and pollution with COVID-19 mortality. The proportion of older people...
Prevalence of obesity and hypovitaminosis D in elderly with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
In elderly patients in Brazil testing positive for COVID-19 admitted to an ICU there was a high prevalence of obesity and low vitamin D levels. Whether or not the obesity and...
-
Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study. Gallery
Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study.
Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study.
Large oral doses of vitamin D taken in the year prior to COVID-19 diagnosis were associated with less severe disease and better survival in frail elderly patients in France...
-
Mortality in an Italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests Gallery
Mortality in an Italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests
Mortality in an Italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests
This observational study identified an inverse relationship between vitamin D treatment and COVID-19 related mortality: those receiving vitamin D supplementation...
Vitamin D and Lung Outcomes in Elderly COVID-19 Patients
In this retrospective cross-sectional study of 65 elderly patients serum, Vitamin D deficiency was associated with more severe lung involvement, longer disease duration, and risk of death in elderly COVID-19 patients.
-
Impact of Vitamin D3 Supplementation on COVID-19 Vaccine Response and Immunoglobulin G Antibodies in Deficient Women: A Randomized Controlled Trial Gallery
Impact of Vitamin D3 Supplementation on COVID-19 Vaccine Response and Immunoglobulin G Antibodies in Deficient Women: A Randomized Controlled Trial
Impact of Vitamin D3 Supplementation on COVID-19 Vaccine Response and Immunoglobulin G Antibodies in Deficient Women: A Randomized Controlled Trial
Impact of Vitamin D3 Supplementation on COVID-19 Vaccine Response and Immunoglobulin G Antibodies in Deficient Women: A Randomized Controlled Trial Take Home Message This small intervention
Towards a Future of Personalized Vaccinology: Study on Individual Variables Influencing the Antibody Response to the COVID-19 Vaccine
Towards a Future of Personalized Vaccinology: Study on Individual Variables Influencing the Antibody Response to the COVID-19 Vaccine Take Home Message Higher vitamin D levels were
Ongoing Studies
Explore current trials being conducted around the world focused on vitamin D and COVID-19.
Title | Status | Conditions | Interventions | Location |
---|---|---|---|---|
Severity of COVID-19 and Vitamin D Supplementation | Active, not recruiting |
|
|
|
Vitamin D Supplementation and Clinical Outcomes in Severe COVID-19 Patients | Active, not recruiting |
|
|
|
Vit D3 for Early Symptoms of COVID-19 | Not yet recruiting |
|
|
|
The Efficacy of Nigella Sativa Versus VitaminD3 as Supplement Therapy in Coronavirus Disease 2019 (COVID-19) | Recruiting |
|
|
|
Low vs. Moderate to High Dose Vitamin D for Prevention of COVID-19 | Recruiting |
|
|
|
Vitamin D Supplementation in Pregnant Women at Risk and COVID-19 | Not yet recruiting |
|
|
|
Baseline Vitamin D Deficiency and COVID-19 Disease Severity | Recruiting |
|
|
|
Vitamin D3 Supplementation to Prevent Respiratory Tract Infections | Active, not recruiting |
|
|
|
Vitamin D for COVID-19 Trial | Active, not recruiting |
|
|
|
High Dose Vitamin-D Substitution in Patients With COVID-19: a Randomized Controlled, Multi Center Study | Active, not recruiting |
|
|
|
Vitamin D Supplementation in the Prevention and Mitigation of COVID-19 Infection | Recruiting |
|
|
|
Vitamin D and COVID-19 Management | Recruiting |
|
|
|
The VITDALIZE Study: Effect of High-dose Vitamin D3 on 28-day Mortality in Adult Critically Ill Patients | Recruiting |
|
|
|
Impact of COVID-19 Vaccination on Serum 25-hydroxyvitamin D Level |
Recruiting |
|
|
|
Vitamin D Supplementation and Clinical Outcomes in Severe COVID-19 Patients | Active, not recruiting | •COVID-19 •Respiratory Distress Syndrome •Vitamin D Deficiency |
•Dietary Supplement: cholecalciferol | •University Hospital Split, Split, Croatia |
Pilot Study of Vitamin K2 (MK-7) and Vitamin D3 Supplementation and the Effects on PASC Symptomatology and Inflammatory Biomarkers | Recruiting | •Post-acute COVID-19 Syndrome | •Dietary Supplement: Vitamin K2 (MK-7) •Dietary Supplement: Vitamin D3 |
|
Long COVID Comorbidities: Endocrine, Metabolic, Neuropsychiatric, Muscle, Cardiovascular, Pulmonary, Dermatologic Dysfunctions | Recruiting | •Long COVID-19 | •Diagnostic Test: Assessments of endocrinological phenotypes of LO-COCO patients
•Diagnostic Test: Assessment of muscular phenotypes of LO-COCO patients •Diagnostic Test: Assessment of •Procedure: Muscle biopsy •Diagnostic Test: Assessment of pulmonary phenotypes of LO-COCO patients •Diagnostic Test: Assessment of •Diagnostic Test: Assessment of vascular phenotypes of LO-COCO patients •Diagnostic Test: Assessment of •Procedure: Tissue biopsy |
•Federico II University of Naples, Naples, Italy |
Severity of COVID-19 and Vitamin D Supplementation | Active, not recruiting | •COVID-19 Respiratory Infection | •Drug: vitamin D | •Almazov National Medical Research Centre, of the Ministry of Health of the Russian Federation, Saint Petersburg, Russian Federation |
Vit D3 for Early Symptoms of COVID-19 | Not yet recruiting | •COVID-19 | •Drug: Standard of care •Dietary Supplement: Vitamin D3 |
•Ayub Teaching Hospital, Abbottabad, Khyber Pakhtunkhwa, Pakistan |
The Efficacy of Nigella Sativa Versus Vitamin D3 as Supplement Therapy in Coronavirus Disease 2019 (COVID-19) | Recruiting | •COVID-19 | •Dietary Supplement: Nigella Sativa capsule twice daily | •Respiratory System specialized hospital at Kobry Elobba Military Medical hospitals., Cairo, Egypt |
Low vs. Moderate to High Dose Vitamin D for Prevention of COVID-19 | Recruiting | •SARS-CoV-2 Infection | •Dietary Supplement: Vitamin D3 | •Rush University Medical Center, Chicago, Illinois, United States •University of Chicago, Chicago, Illinois, United States |
The Effects of a Multi-factorial Rehabilitation Program for Healthcare Workers Suffering From Post-COVID-19 Fatigue Syndrome | Completed | •COVID-19 | •Other: Exercise | •Medical University of Vienna, Vienna, Austria |
Vitamin D Supplementation in Pregnant Women at Risk and COVID-19 | Not yet recruiting | •Pregnancy Complications •COVID-19 |
•Dietary Supplement: Vitamin D supplementation in pregnant women |
•Maria Jose Aguilar Cordero, Granada, Spain |
Magnesium and Vitamin D Combination for Post-COVID Syndrome | Not yet recruiting |
|
|
•Biomedical Research Unit, Durango, Dgo, Mexico |
Baseline Vitamin D Deficiency and COVID-19 Disease Severity | Recruiting | •Vitamin D Deficiency •COVID-19 |
•Other: Vitamin D | •Parkview Medical Center, Pueblo, Colorado, United States |
Vitamin D3 Supplementation to Prevent Respiratory Tract Infections | Active, not recruiting | •Respiratory Tract Infections •COVID-19 •Flu Like Illness |
•Dietary Supplement: Vitamin D supplementation |
•Cooper University Hospital, Camden, New Jersey, United States |
Vitamin D for COVID-19 Trial | Active, not recruiting | •COVID-19 | •Dietary Supplement: vitamin D •Dietary Supplement: Placebo |
•Brigham and Women’s Hospital, Boston, Massachusetts, United States |
High Dose Vitamin D Substitution in Patients With COVID-19: a Randomized, Controlled, Multi Center Study | Active, not recruiting | •COVID-19 •Vitamin D Deficiency •Corona Virus Infection •ARDS •Coronavirus •SARS-CoV Infection |
•Drug: Single high dose vitamin D •Drug: Placebo •Drug: Treatment as usual vitamin D |
•Cantonal Hospital Baselland Liestal, Liestal, BL, Switzerland •Cantonal Hospital St. Gallen, Saint Gallen, SG, Switzerland |
Vitamin D Supplementation in the Prevention and Mitigation of COVID-19 Infection | Recruiting | •COVID-19 •Vitamin D Deficiency •Respiratory Viral Infection |
•Drug: Daily Vitamin D3 •Drug: Daily placebo •Drug: Bolus vitamin D3 •Drug: Bolus placebo |
•Medical Univjuersity of South Carolina, Charleston, South Carolina, United States |
Vitamin D and COVID-19 Management | Recruiting | •COVID-19 | •Dietary Supplement: Ddrops® products, 50,000 IU, Oral •Dietary Supplement: Vitamin D3 |
•University of Alberta, Edmonton, Alberta, Canada |
The VITDALIZE Study: Effect of High-dose Vitamin D3 on 28-day Mortality in Adult Critically Ill Patients | Recruiting | •Critical Illness •Vitamin D Deficiency •COVID-19 |
•Drug: Cholecalciferol •Drug: Placebo |
•LKH Hochsteiermark Standort Bruck, Bruck An Der Mur, Austria •LKH Enzenbach, Enzenbach, Austria •LKH Feldbach, Feldbach, Austria •LKH Fürstenfeld, Fürstenfeld, Austria •Medical University of Graz, Graz, Austria •Medical University Innsbruck, Innsbruck, Austria •Klinikum am Wörthersee, Klagenfurt, Austria •LKH Hochsteiermark Standort Leoben, Leoben, Austria •Barmherzige Brüder Konventhospital Linz, Linz, Austria •Barmherzige Schwestern, Linz, Austria •and 10 more |
The Importance of Vitamin D
What percentage of Americans are vitamin D deficient or insufficient?
The prevalence of vitamin D deficiency was found to be 28.9% and vitamin D insufficiency 41% in a subset of 26,010 US adults surveyed as part of the ongoing National Health and Nutrition Examination Survey (NHANES) 2001-2010.1 Vitamin D deficiency is a major health concern because it has been linked to depression, fatigue, muscle aches, increased risk of respiratory infections, autoimmune disorders, osteoporosis, osteomalacia, osteoarthritis, increased risk of infection and some cancers. Vitamin D insufficiency has been associated with reduced calcium absorption, decreased bone density, potential mild decrease of the blood calcium level, accelerated bone resorption, an increased risk of falls, and potentially fractures. Vitamin D deficiency and insufficiency can seriously affect a person’s quality of life.2,3,4
How is vitamin D different than other vitamins?
Who is more at risk of vitamin D deficiency or insufficiency?
What is the importance of vitamin D in the body?
- Liu X, Baylin A, Levy PD. Vitamin D deficiency and insufficiency among US adults: prevalence, predictors and clinical implications. British Journal of Nutrition. 2018;119(8):928-936.
- Holick MF. The vitamin D deficiency pandemic: a forgotten hormone important for health. Public health reviews. 2010;32(1):267-283.
- Amrein K, Scherkl M, Hoffmann M, et al. Vitamin D deficiency 2.0: an update on the current status worldwide. European journal of clinical nutrition. 2020;74(11):1498-1513.
- MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76(4):1536-1538.)
- Kweder H, Eidi H. Vitamin D deficiency in elderly: Risk factors and drugs impact on vitamin D status. Avicenna J Med. 2018;8(4):139-146. doi:10.4103/ajm.AJM_20_18). 3. https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/#h5
- Emmanuel M. K. Awumey, Devashis A. Mitra, Bruce W. Hollis, Rajiv Kumar, Norman H. Bell, Vitamin D Metabolism Is Altered in Asian Indians in the Southern United States: A Clinical Research Center Study, The Journal of Clinical Endocrinology & Metabolism. 1998; 83(1): 169–173, https://doi.org/10.1210/jcem.83.1.4514
- Castro JP, Penckofer S. The role of vitamin D in the health of Hispanic adults with diabetes. Hisp Health Care Int. 2014;12(2):90-8. doi: 10.1891/1540-4153.12.2.90. PMID: 24871915.
- Sassi F, Tamone C, D’Amelio P. Vitamin D: nutrient, hormone, and immunomodulator. Nutrients. 2018;10(11):1656.
- Hewlings SJ, Medeiros DM. Nutrition: Real People, Real Choices. Pearson Prentice Hall; 2009.
- Elliott ME, Binkley NC, Carnes M, Zimmerman DR, Petersen K, Knapp K, Behlke JM, Ahmann N, Kieser MA. Fracture risks for women in long-term care: high prevalence of calcaneal osteoporosis and hypovitaminosis D. Pharmacotherapy. 2003; Jun;23(6):702-10.
- Nair R, Maseeh A. Vitamin D: The “sunshine” vitamin. J Pharmacol Pharmacother. 2012; Apr;3(2):118-26.
- Bilezikian JP, Bikle D, Hewison M, et al.Mechanisms in Endocrinology: Vitamin D and COVID-19. European Journal of Endocrinology. 2020;183(5):R133-r147.
- van Etten E, Mathieu C. Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. The Journal of steroid biochemistry and molecular biology. 2005;97(1-2):93-101.
- Ginde AA, Mansbach JM, Camargo CA, Jr. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Archives of internal medicine. 2009;169(4):384-390.
- A Kempker, J., & S Martin, G. Vitamin D and sepsis: from associations to causal connections. Inflammation & Allergy-Drug Targets (Formerly Current Drug Targets-Inflammation & Allergy) (Discontinued). 2013; 12(4): 246-252.
- Zdrenghea, M. T., Makrinioti, H., Bagacean, C., Bush, A., Johnston, S. L., and Stanciu, L. A. Vitamin D modulation of innate immune responses to respiratory viral infections, Rev Med Virol. 2017; 27:e1909. doi: 10.1002/rmv.1909.
- Vetter V, Denizer G, Friedland LR, Krishnan J, Shapiro M. Understanding modern-day vaccines: what you need to know. Annals of medicine. 2018;50(2):110-120.
- Cannell JJ, Vieth R, Umhau JC, et al. Epidemic influenza and vitamin D. Epidemiology and infection. 2006;134(6):1129-1140.
- Martineau A R, Jolliffe D A, Hooper R L, Greenberg L, Aloia J F, Bergman P et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data BMJ. 2017; (356):i6583 doi:10.1136/bmj.i6583.
- Zabetakis I, Lordan R, Norton C, Tsoupras A. COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation. Nutrients. 2020 May 19;12(5):1466. doi: 10.3390/nu12051466. PMID: 32438620; PMCID: PMC7284818.
- Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. The Journal of clinical endocrinology and metabolism. 2011;96(1):53-58.
- Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003;77(1):204-210.
- Rosen CJ, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, et al. IOM committee members respond to Endocrine Society vitamin D guidelines. J Clin Endocrinol Metab. 2012;97:1146-52.
- MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011;96:1911-30.
- Amrein K, Scherkl M, Hoffmann M, et al. Vitamin D deficiency 2.0: an update on the current status worldwide. European journal of clinical nutrition. 2020;74(11):1498-1513.