Review the Research

Get summaries of key research on vitamin D and COVID-19

Possible association of vitamin D status with lung involvement and outcome in patients with COVID19: a retrospective study.

Take Home Message

A lower vitamin D status was associated with negative clinical outcomes and decreased survival in hospitalized patients in Iran with COVID-19.

Purpose

To evaluate the prognostic role of serum vitamin D concentration on the extent of lung involvement and final outcomes in patients with COVID-19.

Results

  • Lower concentrations of serum 25(OH)D were significantly associated with a greater extent of lung involvement.
  • Lower concentrations of serum 25(OH)D were significantly associated with poorer outcomes in patients with COVID-19.
  • The odds of death were significantly higher in vitamin D deficient patients (25(OH)D < 25 ng/mL).

 

Who

Seventy-three subjects with a confirmed diagnosis of COVID-19 who were admitted to one hospital in Iran between February 28, 2020 and April 19, 2020.  Average age 55, (47 males, 26 females).

Things to Keep in Mind

  • This study is assessing vitamin D status, not supplementation, and making associations. It doesn’t consider all other aspects of the patient that could influence outcomes.
  • This was not a randomized control trial so it is a bit of a jump for the authors to conclude that supplementation would improve outcomes, the study only suggests an association of vitamin D status and outcomes.
  • The study sample size was small and included only one study center.

 

Author’s Conclusions

This study provides new evidence for clinicians and health policy makers to consider vitamin D supplementation for the improvement of clinical outcomes of patients with COVID-19. We believe that vitamin D might be able to protect patients against developing a severe form of the disease once infected.

Study Design

  • Patients’ demographic data and past medical history including the presence of hypertension, diabetes, ischemic heart disease, asthma, chronic lung disease, chronic liver disease, chronic kidney disease and conditions which might compromise their immune system were recorded.
  • Symptoms including fever, cough, sore throat, dyspnea, chilling, headache, myalgia and gastrointestinal symptoms were collected from medical documents.
  • Vital signs (pulse rate, blood pressure, respiratory rate, body temperature, and oxygen saturation on room air) were recorded for each patient.
  • Patients’ final disease outcome (death vs discharge) was also collected.
  • Serum calcium, phosphorous, magnesium and 25(OH)D were tested.
  • CT scans of the lung were taken.

Reference

Abrishami A, Dalili N, Mohammadi Torbati P, Asgari R, Arab-Ahmadi M, Behnam B, Sanei-Taheri M. Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective study. Eur J Nutr. 2020 Oct 30:1–9. doi: 10.1007/s00394-020-02411-0. Epub ahead of print. PMID: 33123774; PMCID: PMC7595877.

View Full Abstract

Research Summaries

Changes in 25‐hydroxyvitamin D levels post‐vitamin D supplementation in people of Black and Asian ethnicities and its implications during COVID‐19 pandemic: A systematic review

Changes in 25‐hydroxyvitamin D levels post‐vitamin D supplementation in people of Black and Asian ethnicities and its implications during COVID‐19

Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study

Take Home Message Vitamin D deficiency/insufficiency was present in majority of hospitalized patients with COVID-19 or influenza A and correlated with severity and persisted in critical illness survivors at concentrations expected

2022-05-11T13:11:06-05:00