Review the Research

Get summaries of key research on vitamin D and COVID-19

Does vitamin D supplementation reduce COVID-19 severity? – a systematic review 

Take Home Message

This systematic review reports that vitamin D supplementation is effective in reducing COVID19 severity

Results

  • Three Meta-analysis of seven systematic reviews showed strong evidence that vitamin D supplementation reduces the risk of mortality in COVID patients. It was also observed that supplementation reduces the need for intensive care and mechanical ventilation requirement. The findings were said to be robust and reliable because the level of heterogeneity was considerably low. Qualitative analysis showed that supplements (oral and IV) are well tolerated, safe and effective in COVID patients. 

Who

10 reviews were included.

Things to Keep in Mind

  • All systematic reviews are limited by their inclusion and exclusion criteria therefore studies could have been left out 
  • Only 10 of many published reviews were included and those 1 only included from 3 to 13 studies 

Author’s Conclusions

The findings of this study show that vitamin D supplementation is effective in reducing the COVID-19 severity. Hence, vitamin D should be recommended as an adjuvant therapy for COVID-19. However, more robust and larger trials are required to substantiate it further.

Study Design

  • This systematic review assessed the literature to study the effect of vitamin D supplementation on morbidity and mortality in hospitalized COVID-19 patients. Systematic reviews and meta-analysis published from December 2019 to January 2022 presenting the impact of vitamin D supplementation on COVID-19 severity were screened and selected from PubMed and Google scholar.

 

Reference

Shah K, V P V, Sharma U, Mavalankar D. Does vitamin D supplementation reduce COVID-19 severity? – a systematic review. QJM. 2022 Feb 15:hcac040. doi: 10.1093/qjmed/hcac040. Epub ahead of print. PMID: 35166850.

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Research Summaries

Association of vitamin D deficiency with COVID‐19 infection severity: Systematic review and meta‐analysis

Association of vitamin D deficiency with COVID‐19 infection severity: Systematic review and meta‐analysis Take Home Message Vitamin D deficiency leads to poorer outcomes in individuals diagnosed with COVID-19.

Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness.

Pre-infection 25-hydroxyvitamin D3 levels and  association with severity of COVID-19 illness. Take Home Message Vitamin D deficiency is a predictive risk factor associated with poorer COVID-19 clinical disease course and mortality.

COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials.

COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials. Take Home Message Vitamin D use was associated with significant decrease in rates of COVID-19-related events

2022-09-09T11:13:48-05:00