Review the Research

Get summaries of key research on vitamin D and COVID-19

Does vitamin D supplementation reduce COVID-19 severity? – a systematic review 

Take Home Message

This systematic review reports that vitamin D supplementation is effective in reducing COVID19 severity

Results

  • Three Meta-analysis of seven systematic reviews showed strong evidence that vitamin D supplementation reduces the risk of mortality in COVID patients. It was also observed that supplementation reduces the need for intensive care and mechanical ventilation requirement. The findings were said to be robust and reliable because the level of heterogeneity was considerably low. Qualitative analysis showed that supplements (oral and IV) are well tolerated, safe and effective in COVID patients. 

Who

10 reviews were included.

Things to Keep in Mind

  • All systematic reviews are limited by their inclusion and exclusion criteria therefore studies could have been left out 
  • Only 10 of many published reviews were included and those 1 only included from 3 to 13 studies 

Author’s Conclusions

The findings of this study show that vitamin D supplementation is effective in reducing the COVID-19 severity. Hence, vitamin D should be recommended as an adjuvant therapy for COVID-19. However, more robust and larger trials are required to substantiate it further.

Study Design

  • This systematic review assessed the literature to study the effect of vitamin D supplementation on morbidity and mortality in hospitalized COVID-19 patients. Systematic reviews and meta-analysis published from December 2019 to January 2022 presenting the impact of vitamin D supplementation on COVID-19 severity were screened and selected from PubMed and Google scholar.

 

Reference

Shah K, V P V, Sharma U, Mavalankar D. Does vitamin D supplementation reduce COVID-19 severity? – a systematic review. QJM. 2022 Feb 15:hcac040. doi: 10.1093/qjmed/hcac040. Epub ahead of print. PMID: 35166850.

View Full Abstract

Research Summaries

Effect of Vitamin D Supplementation on COVID-19 Patients: A Systematic Review and Meta-Analysis

Effect of Vitamin D Supplementation on COVID-19 Patients: A Systematic Review and Meta-Analysis Take Home Message This meta-analysis found that vitamin D supplementation significantly reduced mortality from COVID-19 in the cohort

Effect of Vitamin D Status on Adult COVID-19 Pneumonia Induced by Delta Variant: A Longitudinal, Real-World Cohort Study

Effect of Vitamin D Status on Adult COVID-19 Pneumonia Induced by Delta Variant: A Longitudinal, Real-World Cohort Study Take Home Message In this small observational study from China in adults with

Is the Vitamin D Status of Patients with COVID-19 Associated with Reduced Mortality? A Systematic Review and Meta-Analysis

Is the Vitamin D Status of Patients with COVID-19 Associated with Reduced Mortality? A Systematic Review and Meta-Analysis Take Home Message his meta-analysis found that overall vitamin D deficiency was associated

2022-09-09T11:13:48-05:00