Review the Research

Get summaries of key research on vitamin D and COVID-19

Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality

Take Home Message

Vitamin D deficiency has a significant dose-response relationship with adverse clinical outcomes of COVID-19 infection, including hospitalization and mortality.

Results

    • 14.5% had vitamin D deficiency (< 20 ng/dl). 
    • African American patients, patients living in areas of high poverty, and those with alcohol and drug use had the highest risk for low vitamin D levels. 
    • There is a significant inverse relationship between vitamin D concentrations and COVID-19 related hospitalization. 
    • Patients with lower vitamin D concentrations, increases in vitamin D are associated with larger reductions in probability for hospitalization than among those with higher vitamin D concentrations. 
    • COVID patients with a vitamin D level of 15 ng/ml compared to 40 ng/ml had a 20% greater with of hospitalization.  
    • COVID patients with a vitamin D level of 15 ng/ml compared to 40 ng/ml had a 53% increased risk of mortality.  

Who

Veterans enrolled in the VA health care systems across the US that tested for COVID-19 (71,175 patients). 4,599 patients had vitamin D levels tested within 15-90 days of their COVID-19 tests. 

Things to Keep in Mind

This is a straightforward chart review and comparison, but it should be noted that these patients were all hospitalized which one can assume means these were the worst cases, and we don’t know about health conditions not reviewed in the study that might increase risk and severity of symptoms or might influence vitamin D status.

 

Author’s Conclusions

Continuous blood 25(OH)D concentrations are independently associated with COVID-19-related hospitalization and mortality in an inverse dose-response relationship in this large racially and ethnically diverse cohort of VA patients. Randomized controlled trials are needed to evaluate the impact of vitamin D supplementation on COVID-19-related outcomes.

Study Design

  • Retrospective Cohort Study

 

Reference

Seal KH, Bertenthal D, Carey E, Grunfeld C, Bikle DD, Lu CM. Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality. J Gen Intern Med. 2022 Jan 1:1–9. doi: 10.1007/s11606-021-07170-0. Epub ahead of print. PMID: 34981368; PMCID: PMC8723909.

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Research Summaries

Association of vitamin D deficiency with COVID‐19 infection severity: Systematic review and meta‐analysis

Association of vitamin D deficiency with COVID‐19 infection severity: Systematic review and meta‐analysis Take Home Message Vitamin D deficiency leads to poorer outcomes in individuals diagnosed with COVID-19.

Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness.

Pre-infection 25-hydroxyvitamin D3 levels and  association with severity of COVID-19 illness. Take Home Message Vitamin D deficiency is a predictive risk factor associated with poorer COVID-19 clinical disease course and mortality.

COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials.

COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials. Take Home Message Vitamin D use was associated with significant decrease in rates of COVID-19-related events

2022-09-09T11:04:46-05:00