Review the Research

Get summaries of key research on vitamin D and COVID-19

Association of vitamin D deficiency with COVID‐19 infection severity: Systematic review and meta‐analysis

Take Home Message

Vitamin D deficiency leads to poorer outcomes in individuals diagnosed with COVID19.

Results

  • Seventeen observational studies with 2756 patients were included in the analyses. 
  • Vitamin D deficiency was associated with significantly higher mortality higher rates of hospital admissions and longer hospital stays as compared to nonvitamin D deficient status. 

Who

Eligible studies (1) included patients with laboratory‐confirmed COVID‐19 diagnosis (polymerase chain reaction [PCR]); (2) documented evaluation of total serum 25‐hydroxyvitamin D (25(OH)D) level within 3 months of COVID‐19 diagnosis; (3) availability of a comparison group: comparing vitamin D deficiency to nondeficiency (includes normal vitamin D status and insufficiency); and (4) reported outcomes of interest (mortality, hospital admission, length of hospital stay and intensive care unit [ICU] admission). 

Things to Keep in Mind

  • Not all studies controlled for confounding
  • Most studies only included older individuals 
  • The cut offs to define vitamin D deficiency were not consistent across studies 

 

Author’s Conclusions

“Vitamin D deficiency is associated with greater COVID‐19 infection severity as measured by rates of mortality, hospital admission and duration of hospital stay. Longitudinal interventional studies are warranted to determine if vitamin D supplementation can decrease COVID‐19 infection severity.”

Study Design

  • Multiple databases from January 1st, 2019 to December 3rd, 2020 were searched for observational studies evaluating the association between vitamin D deficiency and severity of COVID‐19 infection. 
  • The main outcomes of interest were mortality, hospital admission, length of hospital stay and intensive care unit admission. 

 

Reference

Wang Z, Joshi A, Leopold K, Jackson S, Christensen S, Nayfeh T, Mohammed K, Creo A, Tebben P, Kumar S. Association of vitamin D deficiency with COVID-19 infection severity: Systematic review and meta-analysis. Clin Endocrinol (Oxf). 2022 Mar;96(3):281-287. doi: 10.1111/cen.14540. Epub 2021 Jul 12. PMID: 34160843; PMCID: PMC8444883.

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Research Summaries

Association of vitamin D deficiency with COVID‐19 infection severity: Systematic review and meta‐analysis

Association of vitamin D deficiency with COVID‐19 infection severity: Systematic review and meta‐analysis Take Home Message Vitamin D deficiency leads to poorer outcomes in individuals diagnosed with COVID-19.

Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness.

Pre-infection 25-hydroxyvitamin D3 levels and  association with severity of COVID-19 illness. Take Home Message Vitamin D deficiency is a predictive risk factor associated with poorer COVID-19 clinical disease course and mortality.

COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials.

COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials. Take Home Message Vitamin D use was associated with significant decrease in rates of COVID-19-related events

2022-09-13T14:35:22-05:00