Review the Research
Get summaries of key research on vitamin D and COVID-19
Association between vitamin D level and prognostic factors among patients infected with SARS-CoV-2.
Take Home Message
In a cross-sectional study of 68 COVID-19 patients in Iran from March–August 2020, there was no significant associations were observed between vitamin D levels and prognostic factors that included C-reactive protein (CRP), lymphocyte count, D-dimer, lactate dehydrogenase (LDH) and lung high-resolution computed tomography (HRCT) scan score. In addition, vitamin D levels of deceased patients were not significantly different from those of surviving patients.
- Of the twenty-four (35.3%) patients who died due to SARS-CoV-2, 20 (83.3%) were male (p=0.02).
- The mean vitamin D level was 24.1±6 ng/ml (60.25±34 nmol/l).
- No association between vitamin D level and prognostic factors that included CRP, lymphocyte count, D-dimer, LDH and high-resolution computed tomography scan score, was observed.
- Vitamin D levels of the deceased patients were not significantly different from those of surviving patients.
Sixty-eight patients (45 men, 66.2%; 23 women, 33.8%) aged 18-65 years who lacked comorbidities and with a diagnosis of COVID-19 by rRT-PCR test for SARS-CoV-2 detection were enrolled in the study. The mean age of all participants was 52.4±10.4 years.
Things to Keep in Mind
- The observational design of the study cannot substantiate causality between serum vitamin D levels and severity of COVID-19 disease.
- No control group has been included in the study.
- This study had a small sample size. A larger sample size would increase the power and robustness of the study.
The study’s findings indicate no significant relationship between vitamin D level and prognostic factors or outcomes of patients infected with SARS-CoV-2.
- This study was a retrospective cross-sectional study of 68 COVID-19 patients who were admitted to a hospital in Tehran, Iran from March to August 2020.
- The incidence of lung involvement and levels of biochemical markers that included vitamin D level, C-reactive protein (CRP), D-dimer, lymphocyte count, platelet count, white blood cell count, and lactic acid dehydrogenase (LDH), were extracted through medical records.