Association between vitamin D level and prognostic factors among patients infected with SARS-CoV-2.

In a cross-sectional study of 68 COVID-19 patients in Iran from March–August 2020, there was no significant associations were observed between vitamin D levels and prognostic factors that included C-reactive protein (CRP), lymphocyte count, D-dimer, lactate dehydrogenase (LDH) and lung high-resolution computed tomography (HRCT) scan score. In addition, vitamin D levels of deceased patients were not significantly different from those of surviving patients.

• Of the twenty-four (35.3%) patients who died due to SARS-CoV-2, 20 (83.3%) were male (p=0.02).
• The mean vitamin D level was 24.1±6 ng/ml (60.25±34 nmol/l).
• No association between vitamin D level and prognostic factors that included CRP, lymphocyte count, D-dimer, LDH and high-resolution computed tomography scan score, was observed.
• Vitamin D levels of the deceased patients were not significantly different from those of surviving patients.

Sixty-eight patients (45 men, 66.2%; 23 women, 33.8%) aged 18-65 years who lacked comorbidities and with a diagnosis of COVID-19 by rRT-PCR test for SARS-CoV-2 detection were enrolled in the study. The mean age of all participants was 52.4±10.4 years.

• The observational design of the study cannot substantiate causality between serum vitamin D levels and severity of COVID-19 disease.
• No control group has been included in the study.
• This study had a small sample size. A larger sample size would increase the power and robustness of the study.

The study’s findings indicate no significant relationship between vitamin D level and prognostic factors or outcomes of patients infected with SARS-CoV-2.

• This study was a retrospective cross-sectional study of 68 COVID-19 patients who were admitted to a hospital in Tehran, Iran from March to August 2020.
• The incidence of lung involvement and levels of biochemical markers that included vitamin D level, C-reactive protein (CRP), D-dimer, lymphocyte count, platelet count, white blood cell count, and lactic acid dehydrogenase (LDH), were extracted through medical records.

Haghighi M, Ebadi SS, Soleimantabar H, Shadkam A, Ebadi SA, Afzali H. Association between vitamin D level and prognostic factors among patients infected with SARS-CoV-2. Horm Mol Biol Clin Investig. 2021 May 19. doi: 10.1515/hmbci-2021-0008. Epub ahead of print. PMID: 34005841.