COVID‐19 virus induces cytokine production. It induces pro‐ inflammatory responses, proliferates efficiently from the human respiratory tract, those infected with viruses increase pro‐inflammatory cytokine and chemokine production within 24 h. Levels of all viruses tested were measured and high cytokines were found, especially IL‐6, TNF‐α levels were found to be significantly higher. Our data in Table 1 shows that the virus enables uptake and cytokine storm production. High levels of cytokine storm syndrome’ may be one of the critical hallmarks of COVID‐19 disease severity. There is ample evidence that vitamin D is essential for normal immune and lung functions to fight pathogens and prevent autoimmune diseases. It is demonstrated that there exists the potential of vitamin D supplementation to prevent acute respiratory infection by modulating the innate immune response. As vitamin D therapy can reduce the COVID‐19 diseaseburden, so daily supplementation is preferred to better outcomes in COVID‐19 patients. Preventing vitamin D deficiency in patients with severe COVID‐19 seems prudent as vitamin D deficiency is very common and it is associated with both an increased risk of various inflammatory diseases and increased susceptibility to infections including COVID‐19.